The neuroscience of creativity is a topic brimming with impenetrable unknowns.

The  neuroscience of creativity is a topic brimming with impenetrable unknowns. A new study published in the journal Scientific Reports peels back another layer, revealing further mysteries.
No single area of the brain accounts for musical creativity. It is brain-wide enterprise.
It is a given that music has a profound, yet variable, impact on the human brain.
On the one hand, there is the joy or sorrow (or sometimes revulsion) that a melody generates within the listener.
This complex emotional shading experienced by the audience is overlaid with the creative aspects of the human brain responsible for writing and performing the piece.
The present study, carried out by Malinda McPherson and her team at the University of California-San Francisco, took brain scans of jazz musicians as they improvised "happy" or "sad" melodies.
Building on previous work by her colleague Dr. Charles Limb the investigation finds variety in the role of a specific brain area dependent on musical mood. Although insightful, the research adds more intriguing questions to the field of study.

The creative brain
Creativity itself (musical or otherwise) can not be pinned down to one single area of the brain. The scientific consensus is that creativity depends on a myriad of factors and recruits regions across the entire brain.
Some brain area's activities are dampened, some are ramped up; some connections are strengthened, others are quietened.
Although music has a palpable esoteric mysticism about it, every scientist knows that, despite the way it might feel, heavenly emotions, deep musings and sublime euphoria always have their genesis in chemicals and cells. That is the wonder of the human brain....

...One module that is often implicated in musical creation is the dorsolateral prefrontal cortex (DLPFC). During acts of improvisation, the area is effectively switched off.
The DLPFC is implicated in a number of roles including memory, high-level planning and monitoring of behavior, cognitive flexibility and abstract reasoning. It is one of the most recent brain areas in evolutionary terms and does not reach maturity until well into adulthood...

...McPherson says:
There's more deactivation of the DLPFC during happy improvisations, perhaps indicating that people are getting into more of a "groove" or "zone," but during sad improvisations, there's more recruitment of areas of the brain related to reward.This indicates there may be different mechanisms for why it's pleasurable to create happy versus sad music.
Of course, this new layer to our understanding is still a thin layer. Questions still abound. As McPherson says: The notion that we can study complex creativity in artists and musicians from a neuroscientific perspective is an audacious one.
This fascinating glimpse into the neuroscience behind music is part of an ongoing mission to tease apart one of humanity's most culturally ubiquitous and mysterious inventions.
http://www.medicalnewstoday.com/articles/304635.php